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Masoud Vedadi Selected Research

Histone-Lysine N-Methyltransferase

1/2019Identification and characterization of the first fragment hits for SETDB1 Tudor domain.
4/2013Bromo-deaza-SAH: a potent and selective DOT1L inhibitor.
9/2011Optimization of cellular activity of G9a inhibitors 7-aminoalkoxy-quinazolines.
8/2010Protein lysine methyltransferase G9a inhibitors: design, synthesis, and structure activity relationships of 2,4-diamino-7-aminoalkoxy-quinazolines.

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Masoud Vedadi Research Topics

Disease

36Neoplasms (Cancer)
01/2022 - 03/2007
5Breast Neoplasms (Breast Cancer)
10/2020 - 01/2015
5Leukemia
03/2016 - 04/2013
3COVID-19
10/2021 - 01/2021
3Carcinogenesis
01/2015 - 05/2010
2Multiple Myeloma
01/2022 - 11/2021
2Neoplasm Metastasis (Metastasis)
10/2019 - 05/2010
2Brain Neoplasms (Brain Tumor)
01/2010 - 10/2009
1Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
11/2021
1Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
11/2021
1Progeria (Hutchinson Gilford Syndrome)
06/2021
1Premature Aging
06/2021
1Friedreich Ataxia (Friedreich's Ataxia)
12/2020
1Squamous Cell Carcinoma (Epidermoid Carcinoma)
10/2019
1Inflammation (Inflammations)
10/2019
1Lung Neoplasms (Lung Cancer)
01/2019
1Small Cell Lung Carcinoma (Small Cell Lung Cancer)
01/2019
1Genomic Instability
06/2017
1Obesity
03/2016
1Prostatic Neoplasms (Prostate Cancer)
03/2016
1Spinal Muscular Atrophy (Progressive Muscular Atrophy)
01/2016
1Hematologic Neoplasms (Hematological Malignancy)
01/2015
1Triple Negative Breast Neoplasms
01/2015
1Human Influenza (Influenza)
05/2014
1Myeloid Leukemia (Leukemia, Myelocytic)
04/2013
1Cryptosporidiosis
09/2011
1Intellectual Disability (Idiocy)
11/2010
1Fragile X Syndrome (Martin Bell Syndrome)
11/2010
1Pulmonary Embolism
02/2009
1Thrombosis (Thrombus)
02/2009
1Dehydration (Water Stress)
12/2004

Drug/Important Bio-Agent (IBA)

16Proteins (Proteins, Gene)FDA Link
01/2022 - 03/2007
15Histones (Histone)IBA
01/2019 - 01/2010
12Lysine (L-Lysine)FDA Link
11/2021 - 01/2010
9MethyltransferasesIBA
11/2021 - 01/2013
5Protein-Arginine N-Methyltransferases (Methyltransferase, Protein Arginine)IBA
01/2021 - 01/2016
4Protein Isoforms (Isoforms)IBA
01/2022 - 12/2004
4Pharmaceutical PreparationsIBA
01/2021 - 03/2007
4Biological ProductsIBA
01/2021 - 01/2015
4Histone MethyltransferasesIBA
12/2020 - 01/2015
4Histone-Lysine N-MethyltransferaseIBA
01/2019 - 08/2010
3ChromatinIBA
01/2022 - 09/2011
3coactivator-associated arginine methyltransferase 1IBA
10/2020 - 04/2018
3EnzymesIBA
04/2015 - 01/2013
2BI-9321IBA
01/2022 - 01/2019
2Antiviral Agents (Antivirals)IBA
10/2021 - 02/2021
2RNA (Ribonucleic Acid)IBA
06/2021 - 01/2021
2Small Interfering RNA (siRNA)IBA
10/2019 - 01/2015
1Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA
01/2022
1snake venom protein C activatorIBA
01/2022
1Proteolysis Targeting ChimeraIBA
01/2022
1ErbB Receptors (EGF Receptor)IBA
11/2021
1Transcription Factors (Transcription Factor)IBA
10/2021
14- (4- cyanophenyl)- 2- (2- cyclopentylidenehydrazinyl)thiazoleIBA
06/2021
1AcetyltransferasesIBA
06/2021
1Arginine (L-Arginine)FDA Link
01/2021
1MAP Kinase Kinase Kinases (MAP Kinase Kinase Kinase)IBA
01/2021
1Vascular Endothelial Growth Factor Receptor-1 (fms-Like Tyrosine Kinase)IBA
01/2021
1human ERBB2 proteinIBA
01/2021
1FrataxinIBA
12/2020
1human NSD3 proteinIBA
01/2019
1methyl-lysineIBA
01/2019
1Glucose (Dextrose)FDA LinkGeneric
01/2019
1Arabidopsis ATXR5 proteinIBA
06/2017
1Nuclear RNAIBA
03/2016
1UNC3866IBA
03/2016
1LLY-507IBA
05/2015
1UNC1999IBA
01/2015
1Polycomb Repressive Complex 2IBA
01/2015
1Enhancer of Zeste Homolog 2 ProteinIBA
01/2015
1Proliferating Cell Nuclear Antigen (PCNA)IBA
08/2014
1Adenosine (Adenocard)FDA LinkGeneric
04/2013
1ribosomal protein S2IBA
03/2013
1Tumor Suppressor Proteins (Proteins, Tumor Suppressor)IBA
03/2013
1histone H3 trimethyl Lys4IBA
01/2013
1S-Adenosylmethionine (Ademetionine)IBA
01/2012
1Protein MethyltransferasesIBA
01/2012
1Phosphotransferases (Kinase)IBA
09/2011
1S-Phase Kinase-Associated Proteins (Skp1 Protein)IBA
06/2011
15- (3',5'- dichlorobiphenyl- 4- yl)- 2,3- dihydroxy- 4- (2- methoxyacetamido)pentanoic acidIBA
06/2011
1Fragile X Mental Retardation ProteinIBA
11/2010
1RibonucleoproteinsIBA
11/2010
1Messenger RNA (mRNA)IBA
11/2010
1EuchromatinIBA
05/2010
1Peptides (Polypeptides)IBA
01/2010
1Epinephrine (Adrenaline)FDA LinkGeneric
02/2009
1ferric chlorideIBA
02/2009
1Histone Deacetylases (Histone Deacetylase)IBA
04/2008
1SirtuinsIBA
03/2007
1NAD (NADH)IBA
03/2007
1Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA
12/2004

Therapy/Procedure

9Therapeutics
10/2021 - 04/2008
1Oral Administration
01/2015
1Drug Therapy (Chemotherapy)
05/2010